15 September 2026 · The Pharmacist
NICE recommends glycopyrronium bromide cream for hyperhidrosis
The National Institute for Health and Care Excellence (NICE) has recommended a topical prescription cream for the treatment of severe primary axillary hyperhidrosis in adult patients. The guidance covers glycopyrronium bromide cream, marketed under the brand name Axhidrox, for individuals suffering from excessive underarm sweating who cannot tolerate or have not achieved sufficient disease control from conventional therapies.
According to the guidance, the prescription product is indicated following the use of standard non-invasive and medical options. These prior steps include lifestyle measures, topical aluminium-based antiperspirants, and oral medications. The recommendation of topical glycopyrronium bromide offers a targeted option for patients who require escalated treatment when initial management strategies prove unsuccessful or inappropriate.
Prescribing teams, community pharmacies, and digital health services will need to note the placement of this topical treatment within the broader stepped-care pathway for hyperhidrosis. For UK online pharmacies and health platforms, this may require updating clinical assessment protocols and patient consultation questionnaires to verify that individuals have exhausted or cannot use standard first-line therapies prior to obtaining a prescription.